Associate Principal Scientist, In Vivo Pharmacology Job at Merck, South San Francisco, CA

VWVjR1lRb3BYRXFtV0MvYldpcjBwd2M0Tmc9PQ==
  • Merck
  • South San Francisco, CA

Job Description

Merck seeks an Associate Principal Scientist in In Vivo Pharmacology to lead preclinical strategy and model development for cardiometabolic, renal, and respiratory programs at its South San Francisco site. The role combines quantitative pharmacology expertise with scientific leadership to advance drug candidates through translational research and proof-of-concept studies.

Responsibilities

  • Define and execute in vivo model development and pharmacology strategy for preclinical pipeline programs
  • Design and conduct target engagement, pharmacodynamic, and efficacy studies with high scientific standards
  • Lead development, characterization, and validation of in vivo models for mechanism-of-action and compound profiling studies
  • Perform quantitative data analysis and translate findings into actionable insights for project decisions
  • Manage collaborations with internal teams and external partners on study design and execution

Requirements

  • Bachelor's degree with 12+ years, Master's with 8+ years, or Ph.D./PharmD/DVM/MD with 4+ years in pharmacology or related discipline
  • Expertise in quantitative and translational pharmacology including PK/PD, target occupancy, and human dose projection
  • Proven track record developing in vivo pharmacology strategies and disease-relevant models in cardiometabolic, renal, or respiratory areas
  • Strong skills in animal study design and execution for target engagement, efficacy, and safety evaluation
  • Excellent cross-functional collaboration and stakeholder management with ability to influence matrix teams
  • Exceptional written and verbal communication for scientific and business audiences
  • Willingness to work onsite five days per week

Job Tags

Similar Jobs

Nannys&Grannys-Nanny4U

NOT AVAILABLE ANYMORE Elite Full-Time Nanny - Family #1128 Job at Nannys&Grannys-Nanny4U

Elite Full-Time Nanny Family #1128 Southwest Las Vegas | $28$38/hour | MondayFriday About the Position Nanny's & Granny's is seeking an exceptional full-time nanny for a wonderful family in Southwest Las Vegas. This long-term position is perfect for a compassionate...

Eurofins USA PSS Insourcing Solutions

Entry Level Analytical Chemist Job at Eurofins USA PSS Insourcing Solutions

 ...Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients...  ...and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies... 

IQVIA

Bilingual Registered Dietician Clinical Trials Telehealth - Per Diem - Florida Job at IQVIA

 ...Maintain accurate, confidential client records Participate in virtual team meetings and training sessions Requirements...  ...exceptions: CA, MI, NJ, AZ, VA, CO) Minimum 1 year experience coaching and planning with patients Minimum 1 year telehealth practice... 

CRH

Crusher Operator Job at CRH

 ...development of our employees. We strive to be The Preferred Source of quality sand, rock, landscape products, ready-mixed concrete, asphalt, paving and construction services. We succeed as a team by embracing integrity, mutual respect, innovation, service, sustainability, and... 

DeJarnett Sales Inc

Grocery Merchandiser Job at DeJarnett Sales Inc

Position is responsible for new store sets, existing store resets, new item placement and Center Store merchandising within independently owned grocery stores. This includes the use of flow grams (when applicable), placement of new items, setting up displays, organizing...